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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BTK All Species: 23.94
Human Site: S378 Identified Species: 52.67
UniProt: Q06187 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q06187 NP_000052.1 659 76281 S378 S R L K Y P V S Q Q N K N A P
Chimpanzee Pan troglodytes XP_001139051 659 76262 S378 S R L K Y P V S Q Q N K N A P
Rhesus Macaque Macaca mulatta XP_001103213 630 73464 Y359 P T T A G F S Y E K W E I N P
Dog Lupus familis XP_549139 659 76330 S378 S R L K Y P V S Q Q N K N A P
Cat Felis silvestris
Mouse Mus musculus P35991 659 76419 S378 S R L K Y P V S K Q N K N A P
Rat Rattus norvegicus Q07014 512 58642 I242 W D K D A W E I P R E S I K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511258 657 75937 C376 S R L K Y P V C Q R N K N A P
Chicken Gallus gallus Q8JH64 657 75860 S376 S R L K Y P V S R H Q K S A P
Frog Xenopus laevis P13116 532 59718 P262 S K D A W E I P R D S L R L E
Zebra Danio Brachydanio rerio XP_697087 640 73807 S357 S R L K Y I V S N R A Q N A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P08630 786 87374 S502 L A C R L K S S P C D R P V P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 54.4 98.9 N.A. 98.3 31.2 N.A. 93 85.5 32.6 63.4 N.A. 38.9 N.A. N.A. N.A.
Protein Similarity: 100 100 71.9 99.6 N.A. 99.8 48.7 N.A. 96.9 93.4 47.6 78.4 N.A. 52.9 N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 100 N.A. 93.3 0 N.A. 86.6 73.3 6.6 66.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 100 6.6 N.A. 93.3 86.6 40 80 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 19 10 0 0 0 0 0 10 0 0 64 0 % A
% Cys: 0 0 10 0 0 0 0 10 0 10 0 0 0 0 0 % C
% Asp: 0 10 10 10 0 0 0 0 0 10 10 0 0 0 0 % D
% Glu: 0 0 0 0 0 10 10 0 10 0 10 10 0 0 10 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 10 10 0 0 0 0 19 0 0 % I
% Lys: 0 10 10 64 0 10 0 0 10 10 0 55 0 10 0 % K
% Leu: 10 0 64 0 10 0 0 0 0 0 0 10 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 46 0 55 10 0 % N
% Pro: 10 0 0 0 0 55 0 10 19 0 0 0 10 0 82 % P
% Gln: 0 0 0 0 0 0 0 0 37 37 10 10 0 0 0 % Q
% Arg: 0 64 0 10 0 0 0 0 19 28 0 10 10 0 0 % R
% Ser: 73 0 0 0 0 0 19 64 0 0 10 10 10 0 0 % S
% Thr: 0 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 64 0 0 0 0 0 0 10 0 % V
% Trp: 10 0 0 0 10 10 0 0 0 0 10 0 0 0 0 % W
% Tyr: 0 0 0 0 64 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _